BDBM14769 6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-2H-pyridazin-3-one::6-(4-(difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one::6-(4-Difluoromethoxy-3-methoxy-phenyl)-2H-pyridazin-3-one::6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydropyridazin-3-one::CHEMBL313842::Zaradaverine::Zardaverine

SMILES COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1

InChI Key InChIKey=HJMQDJPMQIHLPB-UHFFFAOYSA-N

Data  34 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 14769   

LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  390nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  500nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  210nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant human PDE4D expressed in Escherichia coli assessed as increase in cAMP levels after 60 mins by BIOMOLGREEN dye-based assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  158nMAssay Description:Inhibition of PDE4 in the cytosol of human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  800nMAssay Description:In vitro inhibition of bovine smooth muscle phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  158nMAssay Description:inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human GST-tagged PDE4D catalytic domain (183T to 510S residues) expressed in Escherichia coli cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human GST-tagged PDE4D catalytic domain (183T to 510S residues) expressed in Escherichia coli cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human PDE4 using 5'-AMP or 5'-GMP as substrate by scintillation counting methodMore data for this Ligand-Target Pair